Marek Hamsik, Lorenzo Insigne, Kalidou Koulibaly and Allan miss the Lazio clash, however Dries Mertens and Raul Albiol return for Napoli.
It kicks off on Sunday at 19.30 GMT, click here for a match preview.
Captain Hamsik is still not fully recovered from injury, but is expected to be available next week against Milan.
Amin Younes is trying to find full fitness, while Allan, Insigne and Koulibaly are all suspended.
The good news for Carlo Ancelotti is that Mertens and Albiol are back in the squad after ankle and muscular problems.
Napoli squad for Lazio: Meret, Ospina, Karnezis, Mario Rui, Maksimovic, Albiol, Ghoulam, Luperto, Malcuit, Hysaj, Zielinski, Fabian Ruiz, Rog, Diawara, Verdi, Mertens, Callejon, Milik, Ounas